ABSTRACT
Objective: To clarify correlation between lipoprotein subfraction and different age of coronary heart disease. Methods: A total of 1217 patients with coronary angiography (CAG) confirmed CAD were consecutively enrolled. According to onset age, the patients were divided into 3 groups: Very early CAD group, n=135 patients, ≤45 years, Early CAD group, n=505 patients, male at (45-55) years and female at (45-65) years, Late CAD group, n=577 patients, male>55 years and female>65 years. Meanwhile, there was a Control group, n=72 subjects, ≤45 years with normal CAG. The Lipoprotein system was used to classify lipoprotein subfractions and to analyze the distributions of different particles of high-density lipoprotein (HDL) subfraction and low-density lipoprotein (LDL) subfraction in above 4 groups; to explore the relationship between HDL subfraction and very early CAD occurrence. Results: Compared with other groups, Very early CAD group had decreased large particle of HDL subfraction and increased small particle of LDL subfraction, P<0.05. Logistic regression analysis found that the large particle of HDL subfraction was negatively related to very early CAD occurrence (OR=0.872, 95% CI 0.825-0.922), small particle of LDL subfraction was positively related to very early CAD occurrence (OR=1.038, 95% CI 1.008-1.069). Further multivariate Logistic regression analysis indicated that only large particle of HDL subfraction was obviously negatively related to very early CAD occurrence (OR=0.899, 95% CI 0.848-0.954). Conclusion: Large particle of HDL subfraction was negatively related to very early CAD occurrence which implied it played an important role in very early CAD process.